USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P60891 USC-OGP 2-DE database:  P60891 P60891 General information about the entry View entry in simple text format Entry name PRPS1_HUMAN Primary accession number P60891 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Ribose-phosphate pyrophosphokinase 1; EC=2.7.6.1; AltName: Full=PPRibP; AltName: Full=Phosphoribosyl pyrophosphate synthase I; Short=PRS-I;. Gene name Name=PRPS1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1234: pI=6.98; Mw=33419 Cross-references UniProtKB/Swiss-Prot P60891; PRPS1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PRPS1_HUMAN Primary accession number P60891 Secondary accession number(s) B1ALA8 B2R6T7 B4DNL6 D3DUX6 P09329 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  March 15, 2017 (version 148) Name and origin of the protein Description RecName: Full=Ribose-phosphate pyrophosphokinase 1; EC=2.7.6.1; AltName: Full=PPRibP; AltName: Full=Phosphoribosyl pyrophosphate synthase I; Short=PRS-I; Gene name Name=PRPS1 Encoded on Name=PRPS1 Keywords 3D-structure; Alternative splicing; ATP-binding; Charcot-Marie-Tooth disease; Complete proteome; Deafness; Direct protein sequencing; Disease mutation; Gout; Kinase; Magnesium; Mental retardation; Metal-binding; Neurodegeneration; Neuropathy; Non-syndromic deafness; Nucleotide biosynthesis; Nucleotide-binding; Polymorphism; Reference proteome; Retinitis pigmentosa; Transferase. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X15331; CAA33386.1; -; mRNA EMBL D00860; BAA00733.1; -; mRNA EMBL AK297968; BAG60278.1; -; mRNA EMBL AK312706; BAG35584.1; -; mRNA EMBL AL137787; CAI42173.1; -; Genomic_DNA EMBL AL772400; CAI42173.1; JOINED; Genomic_DNA EMBL AL772400; CAI41098.1; -; Genomic_DNA EMBL AL137787; CAI41098.1; JOINED; Genomic_DNA EMBL CH471120; EAX02709.1; -; Genomic_DNA EMBL CH471120; EAX02710.1; -; Genomic_DNA EMBL CH471120; EAX02711.1; -; Genomic_DNA EMBL BC001605; AAH01605.1; -; mRNA CCDS CCDS14529.1; -. [P60891-1]; . PIR JX0159; KIHUR1; . RefSeq NP_001191331.1; NM_001204402.1; . RefSeq NP_002755.1; NM_002764.3. [P60891-1]; . UniGene Hs.56; -; . PDB 2H06; X-ray; 2.20 A; A/B=1-318 PDB 2H07; X-ray; 2.20 A; A/B=1-318 PDB 2H08; X-ray; 2.50 A; A/B=1-318 PDB 2HCR; X-ray; 2.20 A; A/B=1-318 PDB 3EFH; X-ray; 2.60 A; A/B=1-318 PDB 3S5J; X-ray; 2.02 A; A/B=1-318 PDB 4F8E; X-ray; 2.27 A; A/B=1-318 PDB 4LYG; X-ray; 3.00 A; A/B=1-318 PDB 4LZN; X-ray; 2.14 A; A/B=1-318 PDB 4LZO; X-ray; 3.31 A; A/B=1-318 PDB 4M0P; X-ray; 2.11 A; A/B=1-318 PDB 4M0U; X-ray; 2.74 A; A/B=1-318 PDBsum 2H06; -; . PDBsum 2H07; -; . PDBsum 2H08; -; . PDBsum 2HCR; -; . PDBsum 3EFH; -; . PDBsum 3S5J; -; . PDBsum 4F8E; -; . PDBsum 4LYG; -; . PDBsum 4LZN; -; . PDBsum 4LZO; -; . PDBsum 4M0P; -; . PDBsum 4M0U; -; . ProteinModelPortal P60891; -; . SMR P60891; -; . BioGrid 111615; 49; . DIP DIP-61999N; -; . IntAct P60891; 17; . STRING 9606.ENSP00000361512; -; . BindingDB P60891; -; . ChEMBL CHEMBL2638; -; . iPTMnet P60891; -; . PhosphoSitePlus P60891; -; . SwissPalm P60891; -; . BioMuta PRPS1; -; . DMDM 46397477; -; . UCD-2DPAGE P60891; -; . EPD P60891; -; . MaxQB P60891; -; . PaxDb P60891; -; . PeptideAtlas P60891; -; . PRIDE P60891; -; . DNASU 5631; -; . Ensembl ENST00000372435; ENSP00000361512; ENSG00000147224. [P60891-1]; . GeneID 5631; -; . KEGG hsa:5631; -; . UCSC uc004ene.5; human. [P60891-1]; . CTD 5631; -; . DisGeNET 5631; -; . GeneCards PRPS1; -; . GeneReviews PRPS1; -; . HGNC HGNC:9462; PRPS1; . MalaCards PRPS1; -; . MIM 300661; phenotype; . MIM 301835; phenotype; . MIM 304500; phenotype; . MIM 311070; phenotype; . MIM 311850; gene; . neXtProt NX_P60891; -; . OpenTargets ENSG00000147224; -; . Orphanet 1187; Lethal ataxia with deafness and optic atrophy; . Orphanet 411536; Mild phosphoribosylpyrophosphate synthetase superactivity; . Orphanet 411543; Severe phosphoribosylpyrophosphate synthetase superactivity; . Orphanet 99014; X-linked Charcot-Marie-Tooth disease type 5; . Orphanet 90625; X-linked non-syndromic sensorineural deafness type DFN; . PharmGKB PA33817; -; . eggNOG KOG1448; Eukaryota; . eggNOG COG0462; LUCA; . GeneTree ENSGT00550000074583; -; . HOGENOM HOG000210451; -; . HOVERGEN HBG001520; -; . InParanoid P60891; -; . KO K00948; -; . OMA DGEIMVE; -; . OrthoDB EOG091G0ZG8; -; . PhylomeDB P60891; -; . TreeFam TF106366; -; . BioCyc MetaCyc:HS07410-MONOMER; -; . BRENDA 2.7.6.1; 2681; . Reactome R-HSA-73843; 5-Phosphoribose 1-diphosphate biosynthesis; . UniPathway UPA00087; UER00172; . ChiTaRS PRPS1; human; . EvolutionaryTrace P60891; -; . GenomeRNAi 5631; -; . PRO PR:P60891; -; . Proteomes UP000005640; Chromosome X; . Bgee ENSG00000147224; -; . CleanEx HS_PRPS1; -; . ExpressionAtlas P60891; baseline and differential; . Genevisible P60891; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0043234; C:protein complex; IEA:Ensembl; . GO GO:0002189; C:ribose phosphate diphosphokinase complex; IEA:Ensembl; . GO GO:0043531; F:ADP binding; IEA:Ensembl; . GO GO:0016208; F:AMP binding; IEA:Ensembl; . GO GO:0005524; F:ATP binding; IDA:UniProtKB; . GO GO:0030246; F:carbohydrate binding; IEA:Ensembl; . GO GO:0019003; F:GDP binding; IEA:Ensembl; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0016301; F:kinase activity; IEA:UniProtKB-KW; . GO GO:0000287; F:magnesium ion binding; IEA:Ensembl; . GO GO:0042803; F:protein homodimerization activity; IPI:UniProtKB; . GO GO:0004749; F:ribose phosphate diphosphokinase activity; IDA:UniProtKB; . GO GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; TAS:Reactome; . GO GO:0006167; P:AMP biosynthetic process; IEA:Ensembl; . GO GO:0031100; P:animal organ regeneration; IEA:Ensembl; . GO GO:0046101; P:hypoxanthine biosynthetic process; IMP:UniProtKB; . GO GO:0007399; P:nervous system development; IMP:UniProtKB; . GO GO:0006144; P:purine nucleobase metabolic process; IMP:UniProtKB; . GO GO:0006164; P:purine nucleotide biosynthetic process; IMP:UniProtKB; . GO GO:0006221; P:pyrimidine nucleotide biosynthetic process; NAS:UniProtKB; . GO GO:0034418; P:urate biosynthetic process; IMP:UniProtKB; . CDD cd06223; PRTases_typeI; 1; . Gene3D 3.40.50.2020; -; 2; . HAMAP MF_00583_B; RibP_PPkinase_B; 1; . InterPro IPR000842; PRib_PP_synth_CS; . InterPro IPR029099; Pribosyltran_N; . InterPro IPR000836; PRibTrfase_dom; . InterPro IPR029057; PRTase-like; . InterPro IPR005946; Rib-P_diPkinase; . Pfam PF14572; Pribosyl_synth; 1; . Pfam PF13793; Pribosyltran_N; 1; . SUPFAM SSF53271; SSF53271; 1; . TIGRFAMs TIGR01251; ribP_PPkin; 1; . PROSITE PS00114; PRPP_SYNTHASE; 1; .

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